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Abstract #1052

Amyloid Plaque Detection in Two Alzheimer's Disease Mice Models Using Magnetization Transfer Contrast Imaging.

Christian Bigot1, Greetje Vanhoutte1, Marleen Verhoye1, Christine Van Broeckhoven1, Annemie Van Der Linden1

1biomedical science, University of Antwerp, Antwerp, Belgium

The detection of amyloid plaques is clinically relevant for diagnosis and therapeutic monitoring of Alzheimers disease (AD). In this study, we used magnetization transfer contrast (MTC) imaging in APP/PS1 and BRI mice, two AD mice models developing amyloid plaques in the entire forebrain. The two models differ however in their amyloid plaque composition. APP/PS1 mice develop large compact amyloid plaques, while more diffuse and small compact plaques are present in the brain of BRI mice. An MT effect was detected in APP/PS1 but not in BRI mice, suggesting that large compact amyloid plaques elicit a larger MT-effect.