Nadia Barakat1, MJ Mulcahey2, John Gaughan1, Pallav Shah1, Scott Faro1, Amer Samdani2, Randal Betz2, Jrgen Finsterbusch3, Feroze Mohamed1
1Temple University, Philadelphia, PA, United States; 2Shriners Hospital for Children, Philadelphia, PA, United States; 3University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Few studies have evaluated the diagnostic accuracy of Diffusion Tensor Imaging (DTI) for spinal cord injury (SCI) but none have involved children. In this study the predictive validity of DTI was evaluated by examining its diagnostic accuracy for pediatric cervical SCI in 35 children. The specificity, sensitivity, receiver operating characteristics area under the curve (ROC AUC) and corresponding 95% confidence intervals (CI) of DTI for the ISNCSCI clinical endpoints and MRI level of injury were calculated. Resampling methods were used to validate the estimates from the final models.