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Abstract #1117

Primary Progressive Multiple Sclerosis Spinal Cord Volume Predicts Clinical Motor Scores

Bretta Russell-Schulz1, Anna Bley2, Arshia Seddigh3, William Regan1, Gareth John Barker4, Naomi Sibtain3, Roger Tam1, Anthony L. Traboulsee1, Steven C.R. Williams4, Peter A. Brex3, Shannon H. Kolind1

1University of British Columbia, Vancouver, BC, Canada; 2TU Berlin, Berlin, Germany; 3King's College Hospital, London, United Kingdom; 4Department of Neuroimaging, King's College London, London, United Kingdom

The goal of this study was to determine whether primary progressive multiple sclerosis (PPMS) cervical cord volume (CCV) is related to the MS functional composite score, or its component tests of upper limb motor function (nine-hole peg test), lower limb motor function (timed 25-foot walk) or cognitive function (paced auditory serial addition test). CCV in the PPMS group was significantly lower than for controls, and smaller CCV correlated with longer timed 25-foot walks. CCV was negatively correlated with age in PPMS but not controls.