Abstract #1117

Primary Progressive Multiple Sclerosis Spinal Cord Volume Predicts Clinical Motor Scores

Bretta Russell-Schulz¹, Anna Bley², Arshia Seddigh³, William Regan¹, Gareth John Barker⁴, Naomi Sibtain³, Roger Tam¹, Anthony L. Traboulsee¹, Steven C.R. Williams⁴, Peter A. Brex³, Shannon H. Kolind¹

¹University of British Columbia, Vancouver, BC, Canada; ²TU Berlin, Berlin, Germany; ³King's College Hospital, London, United Kingdom; ⁴Department of Neuroimaging, King's College London, London, United Kingdom

The goal of this study was to determine whether primary progressive multiple sclerosis (PPMS) cervical cord volume (CCV) is related to the MS functional composite score, or its component tests of upper limb motor function (nine-hole peg test), lower limb motor function (timed 25-foot walk) or cognitive function (paced auditory serial addition test). CCV in the PPMS group was significantly lower than for controls, and smaller CCV correlated with longer timed 25-foot walks. CCV was negatively correlated with age in PPMS but not controls.