Abstract #1139

Application of MOBILE (Mapping of Oxygen by Imaging Lipids Relaxation Enhancement) in Stroke : Preclinical and Clinical Studies.

Florence Colliez¹, Caroline Vandeputte², Uwe Himmelreich³, Thierry Duprez⁴, Benedicte Jordan⁵, Bernard Gallez¹, Julie Magat⁶

¹Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium; ²Biomedical Nuclear Magnetic Resonance Unit,, KUL, Leuven, Belgium; ³Biomedical Nuclear Magnetic Resonance Unit,, KU Leuven, Leuven, Belgium; ⁴Radiology and Medical Imaging, St. Luc hospital, Institute of Neuroscience, UCL, Brussels, Belgium; ⁵Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, UCL, Brussels, Belgium; ⁶Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, UCL , Brussels , Belgium

There is a critical need for methods able to monitor dynamically and noninvasively brain oxygenation in clinical practice. Variations in T1 and T2* are potentially valuable magnetic resonance imaging (MRI) tools to quantify changes in tissue oxygenation. T1 is sensitive to dissolved oxygen which acts as a T1-shortening paramagnetic contrast agent. However, this technique lacks of sensitivity. The aim of the current work was to apply the MOBILE technique (for Mapping of Oxygen By Imaging Lipids relaxation Enhancement) to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids, by exploiting the higher solubility of oxygen in lipids than in water on a photothrombic stroke model and clinical strokes.