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Abstract #1140

Hyperoxic BOLD Contrast in Patients with Unilateral Arterial Steno-Occlusive Diseasecomparison with 15O Positron Emission Tomography

Hajime Tamura1, Masanobu Ibaraki2, Kazuhiro Nakamura2, Hideto Toyoshima2, Keisuke Matsubara2, Toshibumi Kinoshita2

1Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan; 2Radiology, Akita Research Institute for Brain and Blood Vessels, Akita, Japan

We aimed to validate the ability of BOLD contrast imaging with mild oxygen challenge to estimate severity of ischemia in patient with unilateral chronic steno-occlusive disease of the internal carotid or middle cerebral artery. For the validation, the BOLD contrast with hyperoxia was compared with the product of deoxyhemoglobin concentration ([dHb]) and cerebral blood volume (CBV) obtained by 15O PET study. A significant correlation between the lesional-contralateral (LC) difference in BOLD contrast and LC difference in the quantity [dHb] 1.5CBV obtained from PET data was observed. Hyperoxic BOLD contrast imaging may be usefl to estimate the severity of ischemia in chronic arterial steno-occlusive disease.