Abstract #1140

Hyperoxic BOLD Contrast in Patients with Unilateral Arterial Steno-Occlusive Diseasecomparison with 15O Positron Emission Tomography

Hajime Tamura¹, Masanobu Ibaraki², Kazuhiro Nakamura², Hideto Toyoshima², Keisuke Matsubara², Toshibumi Kinoshita²

¹Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan; ²Radiology, Akita Research Institute for Brain and Blood Vessels, Akita, Japan

We aimed to validate the ability of BOLD contrast imaging with mild oxygen challenge to estimate severity of ischemia in patient with unilateral chronic steno-occlusive disease of the internal carotid or middle cerebral artery. For the validation, the BOLD contrast with hyperoxia was compared with the product of deoxyhemoglobin concentration ([dHb]) and cerebral blood volume (CBV) obtained by ¹⁵O PET study. A significant correlation between the lesional-contralateral (LC) difference in BOLD contrast and LC difference in the quantity [dHb]^1.5CBV obtained from PET data was observed. Hyperoxic BOLD contrast imaging may be usefl to estimate the severity of ischemia in chronic arterial steno-occlusive disease.