Abstract #1141

Susceptibility Weighted Imaging Based Approach to ΔOEF Quantification Using Propofol and Midazolam as Potential OEF Modulators

Jonathan Goodwin¹, Kohsuke Kudo¹, Yutaka Shinohe², Ikuko Uwano¹, Fumio Yamashita¹, Yutaka Matsumura¹, Tsuyoshi Metoki¹, Kuniaki Ogasawara³, Akira Ogawa³, Makoto Sasaki¹

¹Division of Ultrahigh Field MRI, Iwate Medical University, Yahaba, Iwate, Japan; ²Oral and Maxillofacial Surgery, Iwate Medical University, Morioka, Iwate, Japan; ³Neurosurgery, Iwate Medical University, Morioka, Iwate, Japan

Oxygen extraction fraction (OEF) is considered to be an important indicator of cerebrovascular health. Accurate, non-invasive measurement of OEF has potential benefit for a number of clinical conditions, however currently positron emission tomography (PET) remains the gold standard. In this work we demonstrate the viability of a recently developed, susceptibility weighted imaging (SWI) technique for mapping OEF change in the brain. Through repeated phase imaging during both Propofol and Midazolam sedation and sedation recovery, a significant global reduction was measured during Midazolam sedation (p<0.018), demonstrating the sensitivity of the technique to moderate perturbation of OEF in the brain.