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Abstract #1141

Susceptibility Weighted Imaging Based Approach to ΔOEF Quantification Using Propofol and Midazolam as Potential OEF Modulators

Jonathan Goodwin1, Kohsuke Kudo1, Yutaka Shinohe2, Ikuko Uwano1, Fumio Yamashita1, Yutaka Matsumura1, Tsuyoshi Metoki1, Kuniaki Ogasawara3, Akira Ogawa3, Makoto Sasaki1

1Division of Ultrahigh Field MRI, Iwate Medical University, Yahaba, Iwate, Japan; 2Oral and Maxillofacial Surgery, Iwate Medical University, Morioka, Iwate, Japan; 3Neurosurgery, Iwate Medical University, Morioka, Iwate, Japan

Oxygen extraction fraction (OEF) is considered to be an important indicator of cerebrovascular health. Accurate, non-invasive measurement of OEF has potential benefit for a number of clinical conditions, however currently positron emission tomography (PET) remains the gold standard. In this work we demonstrate the viability of a recently developed, susceptibility weighted imaging (SWI) technique for mapping OEF change in the brain. Through repeated phase imaging during both Propofol and Midazolam sedation and sedation recovery, a significant global reduction was measured during Midazolam sedation (p<0.018), demonstrating the sensitivity of the technique to moderate perturbation of OEF in the brain.