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Abstract #1143

Impaired Cerebro-Vascular Reserve in Carotid Artery Disease Correlates with Deficits in Cognitive Functions

Kay Jann1, Manuela Wapp2, Frauke Kellner-Weldon2, Martinus Hauf2, Yuliya Burren2, Regula Everts2, 3, Marwan El-Koussy2, Patrik Michel4, Gerhard Schroth2, Andrea Federspiel1

1Dept. of Psychiatric Neurophysiology, University Hospital of Psychiatry / University of Bern, Bern, Switzerland; 2Institut of Diagnostic and Interventional Neuroradiology, University of Bern / Inselspital, Bern, Switzerland; 3Division of Neuropediatrics, Children's University Hospital / Inselspital, Bern, Switzerland; 4Department of Neurology, University Hospital Lausanne, Lausanne, Switzerland

In carotid artery disease (CAD) information about cerebral blood flow identifies areas with reduced perfusion due to the flow restriction of a feeding vessel. Moreover the cerebro vascular reactivity (CVR) is often reduced and is suggested to be the physiological basis for observed cognitive deficits in CAD. In this study we found significant reduction of CVR in the anterior watershed area on the stenotic side. In addition, significant negative correlations between AW-CVR on the stenotic side and the neuropsychological performance were found in the domain of verbal working memoryas well as for executive functions confounding the above hypothesis.