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Abstract #1144

Hypoperfusion, Ischemia and Blood Pressure Reduction in Intracerebral Hemorrhage

Didem Aksoy1, 2, Ryan W. Snider1, 2, Jonathan Kleinman1, 2, Michael Mlynash1, 2, Nancy J. Fischbein3, Roland Bammer3, Matus Straka3, Irina Eyngorn1, 2, Alisa Gean4, Chitra Venkat1, 2, Anna K. Finley Caulfield1, 2, Christine Wijman1, 2

1Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, United States; 2Stanford Neurocritical Care Program, Stanford Stroke Center, Stanford University Medical Center, Palo Alto, CA, United States; 3Department of Radiology, Stanford University, Palo Alto, CA, United States; 4Department of Radiology, University of California, San Francisco, San Francisco, CA, United States

In this study, we examined whether large blood pressure reductions are associated with hypoperfusion and ischemia in the perihematomal region in acute intracerebral hemorrhage (ICH) patients. Perfusion and diffusion weighted imaging were performed within 24 hours of ICH onset. Hourly blood pressures were recorded from hospital admission to MRI. Hypoperfusion and presence of diffusion lesions in the perihematomal region were found to be associated with the absolute and percent degree of reduction from admission systolic blood pressure to mean treated systolic blood pressure.