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Abstract #1145

Utility of DSC-MRI Indices as Predictors of Cerebral Perfusion Changes After Carotid Angioplasty with Stenting

Pin-Hsun Huang1, Tsong-Hai Lee2, Feng-Xian Yan1, Ho-Fai Wong3, Ho-Ling Liu1, 3

1Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 2Neurology and Stroke Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 3Medical Image and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

This study aimed to investigate the cerebral hemodynamic changes in patients with carotid stenosis and the utility of DSC-MRI indices for predicting hyper-perfusion phenomenon after carotid angioplasty with stenting (CAS).Fifty-four patients with unilateral internal carotid artery stenosis received DSC-MRI before and one-week after CAS. The CBF, TTP, MTT and Tmax were assessed and correlated with perfusion change after CAS. This study found that perfusion change was negatively correlated with ipsilateral CBF, and positively correlated with ipsilateral Tmax and MTT. Patients with hyper-perfusion after CAS had significantly longer pre-CAS ipsilateral Tmax and MTT as comparing to the other patients.