Abstract #1147

Evaluation of Susceptibility Weighted Imaging in Children with Sickle Cell Disease

Adam M. Winchell¹,², Brian Taylor¹, Paul Grundlehner¹, Ralf B. Loeffler¹, Jane Hankins³, Winfred Wang³, Kathleen Helton¹, Claudia M. Hillenbrand¹

¹Radiological Sciences, St. Jude Childrens Research Hospital, Memphis, TN, United States; ²Biomedical Engineering, University of Memphis, Memphis, TN, United States; ³Hematology, St. Jude Childrens Research Hospital, Memphis, TN, United States

One of the most devastating complications in children with sickle cell disease is stroke. A hessian-based vessel segmentation algorithm was used on SWI to quantify the venous contrast in patients and normal controls. The conspicuity of venous contrast in sickle cell disease is qualitatively less than in controls and shows a significant quantitative decrease. Quantitative measures of venous contrast inversely correlated with basilar tortuosity.