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Abstract #1148

Cerebral Arterial Blood Volume and Blood Flow in Hypertensive and Normotensive Rats

Tae Kim1, Seong-Gi Kim1

1University of Pittsburgh, Pittsburgh, PA, United States

We quantified cerebral arterial blood volume (CBVa) and blood flow (CBF) in eight hypertensive (SHR) and nine normotensive (WKY) rats using magnetization transfer-varied arterial spin labeling technique. Regional CBVa values from SHR were generally smaller than those from WKY, while CBF values were no difference, indicating CBVa is a sensitive biomarker for hypertension. Especially, hippocampus has significantly lower CBVa values for SHR than WKY, indicating that its vascular remodeling and adaption may lead to dementia.