Cerebral Arterial Blood Volume and Blood Flow in Hypertensive and Normotensive Rats

Tae Kim¹, Seong-Gi Kim¹

We quantified cerebral arterial blood volume (CBVa) and blood flow (CBF) in eight hypertensive (SHR) and nine normotensive (WKY) rats using magnetization transfer-varied arterial spin labeling technique. Regional CBVa values from SHR were generally smaller than those from WKY, while CBF values were no difference, indicating CBVa is a sensitive biomarker for hypertension. Especially, hippocampus has significantly lower CBVa values for SHR than WKY, indicating that its vascular remodeling and adaption may lead to dementia.