Cerebral Hemodynamic Impairment Assessed with Resting State FMRI

Shiori Amemiya¹, Akira Kunimatsu¹, Kuni Ohtomo¹

To test the feasibility of hemodynamic impairment assessment using resting-fMRI (rfMRI), temporal dynamics of low-frequency-oscillation in ischemic patients were evaluated. Correlation coefficients between each voxelfs and time-shifted (}20s) global-mean-signal was calculated and the best-fit-shift was determined. Regions showing delayed time-to-peak in DSC-perfusion showed delay in rfMRI. rfMRI maps were highly reproducible and can be used to indicate abnormal perfusion in acute or chronic ischemic patients. Although the approach has the same limitations to other measurements (head motion and hemorrhage), non-invasiveness, simplicity and high reproducibility would be of clinical value as an alternative to current techniques in patient selection.