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Abstract #1186

Disrupted Topological Organization of White Matter Structural Networks in Bipolar Disorder

Fuchun Lin1, Shenhong Weng2, Baojun Xie3, Yunfei Zha3, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences, Wuhan, Hubei, China; 2Department of Psychiatry, Renmin Hospital, Wuhan University, Wuhan, Hubei, China; 3Department of Radiology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China

Network analysis method was used to investigate the architecture of the white matter structural networks bipolar disorder. Although bipolar patients showed a small-world organization of white matter networks, they had significantly decreased network strength, decreased global efficiency and increased shortest path length. Moreover, bipolar patients had reduced efficiencies in several parietal, temporal, frontal, occipital and limbic regions. These findings may improve our understanding of the potential mechanisms of the underlying neurobiological basis of bipolar disorder.