Sylvie J. van der Kruijs1, Shridhar Rajan Jagannathan2, Nynke M. Bodde3, Ren M.H. Besseling1, Richard H. Lazeron3, Kristl E. Vonck4, Paul A. Boon4, Pierre J. Cluitmans2, Geert R. Langereis5, Paul A.M. Hofman1, Walter H. Backes1, Albert P. Aldenkamp3, Jacobus F.A. Jansen1
1Mental Health and Neuroscience, Maastricht University, Maastricht, Limburg, Netherlands; 2Electrical Engineering, University of Technology, Eindhoven, Noord-Brabant, Netherlands; 3Kempenhaeghe, Heeze, Noord-Brabant, Netherlands; 4Neurology, Ghent University Hospital, Ghent, Belgium; 5Industrial Design, University of Technology, Eindhoven, Noord-Brabant, Netherlands
Resting-state fMRI networks of 21 patients with psychogenic non-epileptic seizures (PNES) and 27 healthy controls were investigated using principal independent component analyses. Patients with PNES demonstrated higher coactivation of the orbitofrontal, insular and subcallosal cortex in the resting-state network associated with fronto-parietal activation; the cingulate and insular cortex in the resting-state network associated with executive control; the cingulate gyrus, superior parietal lobe, pre- and postcentral gyri and supplemental motor cortex in the resting-state network associated with sensorimotor functioning; and the precuneus and (para-) cingulate gyri in the default-mode network. Since the network weights within these regions of interest were significantly and positively correlated with dissociation scores, these findings are suggested neurological correlates of the underlying dissociative mechanism of the symptoms.