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Abstract #1215

The Value of Pre-Treatment Dynamic Contrast-Enhanced MR Imaging and Tumor Volume in the Prediction of Nasopharyngeal Carcinoma with Distant Metastasis - A Pilot Study

Shy-Chyi Chin1, 2, Yu-Shi Lin, 23, Ho-Ling Liu, 12

1Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 3Diagnostic Radiology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan

We have derived an imaging metric that combines T1-weighted DCE-MRI parameters and tumor volume to predict the distant metastasis (DM). Preliminary data indicate that the DCE-MRI parameter correlates well with a tumors DM. Patients at risk of DM are sometime undetermined even with PET scan until there is clinical decline or radiologic progression. In clinical practice, knowing which patients will have DM is important to the individualization of care. Thus, tumor volume and DCE-MRI parameters, specifically, the maximal values of the Ktrans,ve and vp can be useful methods for tailoring treatment and improving patient outcomes.