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Abstract #1245

Voxel-Based Morphometric Analysis of Brain in Welders with Chronic Manganese Exposure

Seong-Uk Jin1, Jeehye Seo1, Jang Woo Park1, Moon Han1, Yongmin Chang1, 2, Kyung Jin Suh3

1medical & Biological Engineering, Kyungpook National University, Daegu, Korea; 2Radioloty and molecular medicine, Kyungpook National University, Daegu, Korea; 3Radiology, College of Medicine, Dongguk University, Gyungju, Korea

An increase in the Manganese concentration in the brain is a critical step in Mn neurotoxicity, also known as manganism. It is important question whether the neurobehavioral dysfunctions, which are often found in Mn-exposed welders, are associated with structural brain abnormalities in Mn-exposed welders. Voxel-based morphometry demonstrated voxel-wise comparisons of gray and white matter at a whole-brain level, has been useful in characterizing subtle changes in brain structure in a variety of diseases associated with neurological and psychiatric dysfunction. the present research showed significant correlations between several neurobehavioral deficits and volumetric indices.