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Abstract #1246

Tract Specific Analysis Reveals the Impact of Childhood Manganese Exposure on the Corpus Callosum

Yi Lao*1, 2, Laurie Anne Dion3, Fernando Yepes, 24, Guillaume Gilbert5, 6, Maryse Bouchard5, Dave Saint Amour^3, Natasha Lepore1, 2

1University of Southern California, Los Angeles, CA, United States; 2Children's Hospital Los Angeles, Los Angeles, CA, United States; 3Universit du Qubec Montral, Montreal, QC, Canada; 4University of Barcelona, Barcelona, Catalua, Spain; 5Universit de Montral, Montral, QC, Canada; 6Philips Healthcare, Montreal, QC, Canada

Long-term Manganese exposure(Mn) will cause neuromotor and deficits. However, studies focusing on the adverse effects of Mn on white matter microstructures are few in number. Moreover, white matter structures may not be accurately mapped in traditional voxel-based analysis which is widely used in related studies.