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Abstract #1247

Effect of Exenatide (A Weight Loss Drug) on fMRI Response to Food-Cues in Lean and Obese

Claudia Huerta1, Roy Eldor1, Muhammad Abdul-Ghani1, Ralph DeFronzo1, Timothy O. Duong2

1UTHSCSA, San Antonio, TX, United States; 2UT Health Science Center at San Antonio, San Antonio, TX, United States

In this study, we propose to investigate the neural response to visual food cues utilizing fMRI in lean and obese subjects pre and post intravenously infusion of Exenatide, a synthetic version of the gut peptide GLP-1 (glucagon-like peptide-1), it is known to increase satiety and promotes weight loss. Lean showed an increased response in motivation, cognitive control and decision-making components of food intake regulation after Exenatide, whereas obese subjects showed increased neural response following Exenatide infusion only in a few structures classified in the motivation component.