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Abstract #1248

Quantitative Study of Changes in Multi-Parametric MRI Markers Post-Laser Interstitial Ablation Therapy (LITT) for Epilespy

Pallavi Tiwari1, Shabbar Danish2, Anant Madabhushi1

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Neurology, University of Medicine and Dentistry, New Jersey, New Brunswick, NJ, United States

In this work, we quantitatively evaluate changes in multi parametric MRI (MP-MRI) imaging markers (T1-w, T2-w, T2-GRE, T2-FLAIR, and ADC) over the epileptogenic foci, pre- and post- laser interstitial thermal therapy (LITT), to (a) identify MR imaging markers that change most-dramatically over time while computing treatment related changes post-LITT, and (b) develop a weighted temporal MP-MRI signature corresponding to successful / unsuccessful treatment, by combining the imaging markers identified as most contributory in evaluating treatment related changes at different time points post-LITT, in a cohort of epilepsy patients.