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Abstract #1265

Mn Concentration Mapping with MRI: Comparision with Autoradiography and PET

Geoffrey Topping1, Andrew Yung2, Paul Schaffer3, Cornelia Hoehr3, Thomas Ruth3, Piotr Kozlowski2, Vesna Sossi1

1Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada; 2MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; 3Nuclear Medicine, TRIUMF, Vancouver, BC, Canada

Mn concentration is mapped in rat brain with MRI, PET, and autoradiography after intracerebroventricular or intraperitoneal injection. Images of the same animals in three modalities are compared. MR relaxivity change from baseline is measured with a Look-Locker sequence. Mn-52 was produced by proton irradiation of Cr foil and used as a radiotracer for PET and autoradiography. MRI has sufficient resolution to resolve structural details, but shows artifacts in regions of high Mn concentration. PET has poor resolution, but is more consistent than MRI with autoradiography results.