Abstract #1279

Assessment of Post Infarct Remodeling in CCR2 Knockout and Wild Type Mice with an Elastin-Binding Contrast Agent

Britta Butzbach¹, Andrea Protti², Xuebin Dong², Frank Tacke³, Matthias Bartneck³, David Onthank⁴, Eike Nagel¹, Ajay Shah⁵, Rene M. Botnar¹

¹Imaging Sciences, Rayne's Institute, London, Middlesex, United Kingdom; ²Cardiovascular division, Cardiology, London, Middlesex, United Kingdom; ³Medical clinic III, Gastroenterology, Aachen, Nordrhein Westfalen, Germany; ⁴Discovery Biology and Veterinary Sciences at Lantheus Medical Imaging, Boston, North Billerica, United States; ⁵Cardiovascular Division, Cardiology, London, Middlesex, United Kingdom

Assessment of post infarct remodelling in CCR2 and wild type mice was conducted with an elastin-binding contrast agent. MRI was compared with histology and shows that imaging of post infarct remodelling is feasible with an elastin-binding contrast agent. 7 days after permanent ligation there was less elastin amount in CCR2-knockout mice with increased infarct size and the ejection fraction was lower compared to wild type mice. After 1 month the ejection fraction in CCR2-knockout mice was lower compared to wild type mice and the infarct size was increased.