Meeting Banner
Abstract #1344

Comparison of MRI and US Assessment of Vascular Reactivity in Relation to CVD Risk Factors in Old and Young Healthy Subjects

Erica Chirico1, Michael C. Langham, Erin K. Englund, Susan Schultz1, Lifeng Zhang2, Sandy Sehgal1, Emile R. Mohler2, Felix W. Wehrli

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Medicine, Cardiovascular Division, Vascular Medicine Section, University of Pennsylvania, Philadelphia, PA, United States

We evaluated an integrated MRI protocol that consists of three quantitative techniques against established ultrasound (US) measures: flow-mediated dilation (FMD) of brachial artery and intima-media thickness (IMT) of carotid arteries. MRI techniques included dynamic velocimetry and oximetry in femoral artery and vein, respectively, and regional quantification of pulse-wave velocity in the aortic arch, thoracoabdominal aorta and iliofemoral arteries. The subjects consisted of healthy young and old without a history of cardiovascular disease. Initial results indicate that age-related decline in vascular reactivity are characterized by both MRI and US.