Hung-Hsuan Wang1, Wen-Yih Isaac Tseng2, Hsi-Yu Yu3, Hsu-Hsia Peng1
1Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu City, Taiwan; 2Center for Optoelectronic Biomedicine, National Taiwan University Medical College, Taipei City, Taiwan; 3Department of Surgery, National Taiwan University Hospital, Taipei City, Taiwan
Pulmonary arterial hypertension (PAH) is a deadly disease with a high mortality rate of 20-40% within three years after identification of diagnosis. Previous studies have proposed that the condition of low shear stress (SS) can activate endothelial cells (ECs) to produce vasoconstrictor substances and to inhibit vasodilator substances and therefore may cause vasoconstriction. In our previous study, a number of hemodynamic parameters have been used to differentiate patients with PAH from normal group. In this study, we aim to compute indices of wall shear stress (WSS) and oscillatory shear index (OSI) to investigate differences between normal subjects and PAH patients.