1Wolfson
Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; 2Department
of Pharmacology, University of Cambridge, Cambridge, United Kingdom; 3Behavioural
and Clinical Neuroscience Institute, University of Cambridge, Cambridge,
United Kingdom
Recent studies have demonstrated cardiac pathology in mouse models of Huntington's disease. Here we show that R6/2 mice have specific and progressive right ventricular failure. This phenotype is evident at an advanced state of the disease, but can be seen much earlier performing a dobutamine stress test. In particular, the presence of this pathology can be unmasked by dobutamine at 10 weeks of age, before the mice show any other transgenic phenotype.
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