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Abstract #1394

Comparison of Myocardial T1-Mapping Protocols: Accuracy and Precision

Peter Kellman1, Hui Xue2, Michael Schacht Hansen3

1NHLBI, NIH, Bethesda, MD, United States; 2Siemens Corporate Research, Princeton, NJ, United States; 3NHLBI, National Institutes of Health, Bethesda, MD, United States

Both accuracy and precision of T1-mapping are important for quantitative measurements and reliable detection of abnormal elevation of T1. Accuracy reflects the systematic or bias errors while precision reflects the random error due to noise. The accuracy and precision of several popular methods, including inversion recovery and saturation recovery schemes, are investigated in detail using a waveform level Bloch simulation to assess accuracy, and Monte-Carlo method of repeated trials to assess precision. Simulations are confirmed with phantom measurements.