Michelle Fitts1, 2, Elodie Breton3, Eugene G. Kholmovski2, 4, Derek J. Dosdall2, 5, Sathya Vijayakumar, 24, Kyung P. Hong1, 2, Ravi Ranjan2, 5, Nassir F. Marrouche2, 5, Leon Axel6, Daniel Kim2, 4
1Bioengineering, University of Utah, Salt Lake City, UT, United States; 2CARMA Center, University of Utah, Salt Lake City, UT, United States; 3ICube, Strasbourg University, Strasbourg, Alsace, France; 4UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, United States; 5Internal Medicine, University of Utah, Salt Lake City, UT, United States; 6Department of Radiology, New York University, New York, United States
We present a cardiac T1 mapping pulse sequence based on saturation recovery, which is arrhythmia-insensitive and rapid (AIR) for assessment of diffuse fibrosis. We compared its performance against the conventional cardiac T1 mapping inversion recovery based method, MOLLI, which is sensitive to heart rate and rhythm conditions, using an IR fast spin-echo sequence for reference. In vitro studies demonstrated that T1 measurements made by AIR were more precise and accurate than MOLLI at different heart rate and rhythm conditions. More work is needed to validate diagnostic accuracy and precision in patients with tachycardia and/or arrhythmias.