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Abstract #1464

Inter-Lung Differences in 3He Diffusion MRI in Young Adults with Congenital Diaphragmatic Hernia: Analysis Using a Stretched Exponential Model

Juan Parra-Robles1, Helen Marshall1, Marjolein Spoel2, Hanneke IJsselstijn2, Dick Tibboel2, Harm Tiddens3, Jim M. Wild1

1Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom; 2Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Childrens Hospital, Rotterdam, Netherlands; 3Department of Pediatrics- Respiratory Medicine and Allergology, Erasmus MC-Sophia Childrens Hospital, Rotterdam, Netherlands

In this work we use a stretched exponential model of 3He diffusion MR to assess changes in lung microstructure in young adults with Congenital Diaphragmatic Hernia. Diffusivity DDC values were significantly elevated in the left lung of 8 of the 9 patients, while interlung differences in heterogeneity index &[alpha] were present only in 6 patients. Our results have shown that although most patients presented airway enlargement in the left lung, microstructural changes related to the developmental defect of the diaphragm only occur in some of them.