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Abstract #1481

Validation of Two-Compartment Inversion Recovery (TCIR) MRI in a Multimodal Animal Study

Thomas Gaass1, Grzegorz Bauman2, 3, Julien Dinkel4, 5, Axel Haase1, Christian Hintze6

1Zentralinstitut fr Medizintechnik, Technische Universitt Mnchen, Garching, Germany; 2Department of Medical Physics, German Cancer Research Center, Heidelberg, Germany; 3Department of Medical Physics, University of Wisconsin, Madison, WI, United States; 4Department of Radiology, German Cancer Research Center, Heidelberg, Germany; 5Massachusetts General Hospital, Boston, MA, United States; 6Diagnostische Radiologie, Universittsklinikum Schleswig-Holstein, Kiel, Germany

The presented work aims to compare maps of the fractional pulmonary blood volume (fPBV) generated using the Two-Compartment Inversion Recovery (TCIR) method to the clinical reference standard single photon emission computed tomography/computed tomography (SPECT/CT) in an animal experiment. For the assessment of the performance of TCIR seven anesthetized pigs were studied via CT, as well as dynamic contrast enhanced MRI and SPECT. This animal experiment demonstrated a qualitative agreement in the assessment of blood distribution between contrast agent free TCIR and DCE MRI and conventional SPECT/CT.