Abstract #1505

in vitro and in vivo 19-Fluorine Magnetic Resonance Imaging (MRI) of β-Cells and Pancreatics Using GLUT-2 Specific Contrast Agents

Sayuan Liang¹, Hauke Kolster¹, Karim Louchami², Tom Dresselaers¹, Willy Malaisse², Sonu Sharma¹, Uwe Himmelreich³

¹Biomedical MRI unit/MoSAIC, Department of Imaging and Pathology, K.U.Leuven, Leuven, Belgium; ²Laboratory of Experimental Hormonology, Universit Libre de Bruxelles, Bruxelles, Belgium; ³Biomedical MRI unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium

The purpose of this project is to validate β-cell and pancreatic islet imaging by using fluorinated, GLUT2 targeting mannoheptulose derivatives (FMH) in vivo. We have established a