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Abstract #1533

Quantification of IVIM Diffusion Parameters of HCC at 3T: Preliminary Experience.

Suguru Kakite1, Hadrien A. Dyvorne1, Karen M. Lee1, Sasan Roayaie2, Ashley Knight-Greenfield1, Ersin Bayram3, Claudia Donnerhack1, Bachir Taouli1

1Department of Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2Department of Surgery, Mount Sinai Medical Center, New York, NY, United States; 3GE Healthcare, Milwaukee, WI, United States

IVIM diffusion parameters and ADC values were quantified in 79 HCCs and liver parenchyma in 46 patients at 3T. D (true diffusion coefficient), PF (perfusion fraction) and ADC were all significantly higher in HCC compared to cirrhotic liver parenchyma. There were also significant correlations between D/PF/ADC and tumor necrosis in treated HCCs. There were significant differences in D/ADC and no significant difference in PF between necrotic components and viable components. The ADC value in the necrotic lesion is more affected by the value of D and less affected by the value of PF.