Katja Hueper1, Martin Meier2, Marcel Gutberlet1, Song Rong3, Xia Lu4, Hermann Haller3, Frank Wacker1, Dagmar Hartung1, Faikah Gueler3
1Radiology, Hannover Medical School, Hannover, Germany; 2Institute of Animal Science, Hannover Medical School, Hannover, Germany; 3Nephrology, Hannover Medical School, Hannover, Germany; 4Zunyi Medical College, Wuhan, China
We investigated whether T2mapping and diffusion weighted imaging (DWI) allow monitoring renal pathology after ischemia induced acute kidney injury (AKI) in mice. T2-changes after AKI were most pronounced in the outer medulla. T2-increase was significantly higher after severe than after moderate AKI and correlated with kidney volume loss at d28. ADC was significantly reduced after AKI till d28 and ADC-reduction was more pronounced after severe AKI. Correspondingly, fibrosis and inflammatory cell infiltration were higher after severe than after moderate AKI. Thus, T2mapping and DWI may help to non-invasively determine presence and severity of acute and chronic changes after AKI.