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Abstract #1549

Functional Evaluation of Acute Ischemia-Reperfusion Injury Using Diffusion-Weighted Imaging

Bin Chen1, Jian Dong2, Wenchao Cai2, Xiaoying Wang, 12, Jue Zhang, 13, Jing Fang, 13

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2Dept. of Radiology, Peking University First Hospital, Beijing, China; 3College of Engineering, Peking University, Beijing, China

MR diffusion-weighted imaging (DWI) is a noninvasive method to provide functional status of acute ischemia/reperfusion (IR) injury in kidney. The purpose of this study was to verify the possibility of DWI to evaluate the functional alterations in kidneys following IR injury in a rabbit model. ADC values of the cortex after ischemia was significantly lower than baselines in the IR injured kidney and recover to the baseline after release, while no significant alterations were found in cortex and outer medulla in the control group. DWI is a sensitive MR tool for characterizing the renal dysfunction.