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Abstract #1550

Functional Evaluation of Acute Ischemia/reperfusion Injury Using BOLD and Arterial Spin Labeling MRI

Bin Chen1, Jian Dong2, Wenchao Cai2, Xiaoying Wang, 12, Jue Zhang, 13, Jing Fang, 13

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2Dept. of Radiology, Peking University First Hospital, Beijing, China; 3College of Engineering, Peking University, Beijing, China

Ischemia/reperfusion injury is considered the leading cause of acute renal failure, and frequently occurs in clinic, such as renal transplantation, shock and vascular surgery. Noninvasive MRI techniques, BOLD combined with ASL have been used in this study to provide novel insights into renal physiology and pathophysiology following normothermic IR injury in rabbit model. BOLD imaging could discriminate different renal structures and is capable for evaluation of intrarenal oxygenation; meanwhile, ASL MRI is available for quantitative renal perfusion. The feasibility of monitoring acute ischemia/reperfusion injury was demonstrated and using BOLD and ASL could provide detection of contralateral renal compensation.