2, Yong Chen1, Bernadette O. Erokwu1, Lan Lu1,
Katherine MacRae Dell3, Chris A. Flask1, 2
Case Western Reserve University, Cleveland, OH, United States; 2Biomedical
Engineering, Case Western Reserve University, Cleveland, OH, United States; 3Pediatrics,
Case Western Reserve University, Cleveland, OH, United States
Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a multiorgan pediatric disease that manifests as progressively increasing renal cysts as well as liver biliary dilatation and congenital hepatic fibrosis. Unfortunately, there are no tools available to effectively monitor ARPKD kidney and liver disease progression which directly limits the development of therapeutic trials. We are currently developing quantitative MRI assessments of ARPKD kidney and liver disease using the PCK rat model that exhibits both kidney and liver diseases associated with ARPKD. In this study we have developed an improved T2 relaxation acquisition to reliably distinguish renal and hepatic pathology from healthy tissue.