Abstract #1557

Single Kidney Glomerular Filtration Rate Measurement Using a High Spatiotemporal Resolution View Sharing Technique and 2-Compartment Model

Umit Yoruk¹, Manojkumar Saranathan², Brian Andrew Hargreaves², Shreyas S. Vasanawala²

¹Electrical Engineering, Stanford University, Palo Alto, CA, United States; ²Radiology, Stanford University, Stanford, CA, United States

Glomerular filtration rate (GFR) is an indicator of kidney function and can be measured by dynamic MR Urography (MRU). We assess the GFR estimation based on a high spatiotemporal resolution DCE method called DISCO. The acquisition parameters affect the temporal resolution and the temporal footprint of the dataset. We optimized the acquisition strategy by creating a digital phantom (based on 2-compartment model), simulating the acquisition with different parameters and comparing the estimated Ktrans to the original Ktrans value we used to create the phantom. Upon validation of the method, we presented a clinical case to demonstrate DISCO-MRU.