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Abstract #1563

A High T1-Relaxivity Nanoparticle for in Vivo MRI Detection of Kidney Glomeruli

Scott Charles Beeman1, Maria Veronica Clavijo Jordan1, Edwin J. Baldelomar1, Kevin M. Bennett1

1Arizona State University, Tempe, AZ, United States

The goal of this work is to develop a non-invasive, MRI-based method for detecting kidney glomeruli in vivo. We have previously shown that kidney glomeruli may be detected in vivo using the glomerulus-specific contrast agent cationized ferritin (CF), though it is quite difficult to detect the superparamagnetic CF against the dark blood background of the kidney. Here we show that a paramagnetic version of CF, called paraCF, may be created to label kidney glomeruli and render then highly detectable in vivo with T1-weighted MRI.