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Abstract #1562

Glomerular Imaging of Mouse Kidney Using a Dedicated Alderman-Grant Probe

Jorge Chacon Caldera1, Philipp Krmer1, Raffi Kalayciyan1, Lothar R. Schad1, Sabine Neudecker2, Stefania Geraci2, Norbert Gretz2

1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 2Institute for Medical Technology, Heidelberg University, Mannheim, Germany

The filtration of the blood to maintain balance between salt and water, and the waste elimination is performed in the kidneys by the glomeruli. Glomerular number is, therefore, a very important indicator of the functioning status of the kidneys. Quantification of glomeruli could help diagnose kidney malfunctioning and prevent CKD. The Alderman-Grant resonator is a volumetric probe, which solves the problem of homogeneity; it has good response in UHF so it can be flexible in the dimensions while being efficient at high field NMR [4]. An Alderman-Grant resonator was chosen for its characteristics that match the requirements of the glomerular imaging, and a dedicated MRI probe was built. A comparison between a cryogenic surface probe and the dedicated AVR probe for glomerular imaging is presented.