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Abstract #1599

Simple Ultrashort Echo Time MRI Measure Associated with Cortical Bone Porosity

Mahdieh Bashoor-Zadeh1, Cheng Li1, Wenli Sun1, Maite Aznarez-Sanado1, Alexander C. Wright1, Antonios Zavaliangos2, Chamith S. Rajapakse1

1University of Pennsylvania, Philadelphia, PA, United States; 2Drexel University, Philadelphia, PA, United States

Due to limitations in resolution and other factors, microstructure of CB pore spaces cannot be resolved by clinical imaging. The purpose of this study was to derive a parameter associated with CB porosity using a clinically feasible UTE sequence. Human cortical bone samples were imaged using UTE and micro-CT. A measure associated with cortical bone porosity (called porosity index) was obtained by taking the ratio between two images acquired to include proton signal from only free water in pore spaces and total bone water content. Porosity index was highly correlated with micro-CT derived porosity and moderately correlated with age.