Abstract #1692

Longitudinal Functional Imaging of the HER-2/Neu Transgenic Mouse Model of Human Breast Cancer by DCE-MRI and Diffusion Weighted Imaging

Dario Livio Longo¹,², Lorena Consolino¹,², Stefania Lanzardo³, Walter Dastr¹,², Federica Cavallo⁴, Silvio Aime¹,²

¹Dept. of Chemistry, University of Turin, Torino, Italy; ²Molecular Imaging Center, Torino, Italy; ³Dept. of Clinical and Biological Sciences , University of Turin, Torino, Italy; ⁴Dept. of Clinical and Biological Sciences, University of Turin, Torino, Italy

Identification of imaging biomarkers associated with the multi-step progression of mammary carcinogenesis is a mandatory step in the development of targeted therapies for breast cancer. The combination of imaging techniques allowing to extract important features related to changes in vascular perfusion/permeability, as well as in tissue cellularity may be exploited to characterize important feature of the transition of these earliest stage breast cancers. In this study we assessed the longitudinal changes in the mammary glands of the HER-2/Neu transgenic mouse models by DCE and DWI MRI.