Decrease in Convective Transport Is Associated with Increase in Voxels Explained by Gadolinium Diffusivity in DCE MRI of Untreated Human Gastric Cancer Xenografts

Septian Hartono¹, Tong San Koh¹, Quan Sing Ng¹, Puor Sherng Lee¹, Laurent Martarello², The Hung Huynh¹, Choon Hua Thng¹

Growing tumors eventually develop a high interstitial fluid pressure state that shuts down convective interstitial transport and results in central necrotic areas. Gadolinium diffusivity has been reported as a means of characterizing tracer transport where convective transport is absent. We aim to characterize the temporal change of microcirculatory parameters in gastric cancer xenografts with DCE MRI and to determine the time point where gadolinium transport explained by diffusivity is observed.