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Abstract #1699

A Noninvasive Tumor Oxygenation Imaging Strategy Using MR Imaging of Endogenous Blood and Tissue Water

Zhongwei Zhang1, Rami R. Hallac1, Peter Peschke2, Ralph P. Mason1

1Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany

Tissue oxygenation is an important physiological parameter related to perfusion and metabolism. Oxygen partial pressure (pO2) is a crucial factor in the response of tumors to irradiation and other cytotoxic. In this study, we proposed a new approach that attempts to non-invasively determine tumor pO2 using multi-parametric 1H MRI-based OXygen Imaging (MOXI) strategy. The proposed strategy for pO2 measurements was compared with 19F MRI based on the oxygen reporter molecule hexafluorobenzene (HFB), the correlation with 19F MRI oximetry confirmed the accuracy of tumor pO2 measurements.