Lu Jiang1,
Jannie P. Wijnen2, Tiffany Greenwood1, W.J.M. van der
Kemp2, Dennis W. J. Klomp2, Kristine Glunde3
1Division
of Cancer Imaging Research, Department of Radoilogy, Johns Hopkins School of
Medicine, BALTIMORE, MD, United States; 2Radiology Department,
University Medical Centre Utrecht, Utrecht, Netherlands; 3Division
of Cancer Imaging Research, Department of Radoilogy, Johns Hopkins
University, BALTIMORE, MD, United States
The adiabatic version of refocused insensitive nuclei enhanced by polarization transfer (BINEPT) and pulse acquire (PA) 31P Magnetic Resonance Spectroscopy (MRS) are compared in MCF-7 and MDA-MB-231 breast cancer xenografts at 9.4 Tesla. After in vivo MRS measurements, the tumors were extracted and high-resolution (HR) 31P MRS was performed. Our data suggest that BINEPT can be advantageous for studying the individual compounds in phospholipid metabolism in both the choline and ethanolamine cycle, in translational research in breast cancer and other cancers in vivo at high magnetic field strength.
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