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Abstract #1713

Tissue Redox Activity as a Sensing Platform for Imaging of Cancer Based on Nitroxide Redox Cycle

Rumiana Bakalova1, Zhivko Zhelev1, 2, Ichio Aoki1, Daisuke Kokuryo1, Veselina Gadjeva2, Tsuneo Saga1

1Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; 2Medical Faculty, Trakia University, Stara Zagora, Bulgaria

Redox signalling is crucial for carcinogenesis and our study shows that tissue redox activity can be used as a sensing platform for imaging of cancer, using nitroxide-enhanced MRI. The experiments were conducted on cancer-bearing and healthy mice. The tissues (cancer and non-cancer) of cancer-bearing mice were characterized by a long-lived MRI signal (&[tau] 1/2>14min.),indicating a high oxidative activity. The tissues of healthy mice were characterized by a short-lived MRI signal (&[tau] 1/2<3min.), indicating a high reducing activity to the nitroxide. The proposed methodology is applicable on biopsy specimens and blood samples for evaluation of the effectiveness of anti-cancer therapy.