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Abstract #1718

Assessment of Chemotherapy in a Mouse Model of Non-Hodgkin's Lymphoma Using Dynamic Contrast-Enhanced (DCE) and Diffusion Weighted (DW) MRI

Ramesh Paudyal1, Kavindra Nath Pathak1, Seungcheol Lee1, Kejia Cai1, Stephen B. Pickup1, David Nelson1, Harish Poptani1, Jerry D. Glickson1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

In this study, we investigated the potential of combining dynamic contrast enhanced MRI and diffusion weighted imaging method for evaluating the response of RCHOP in non- Hodgkin lymphoma. Our results suggest that the change in kinetic model parameters and ADC values after the administration of RCHOP can be used a as an indicator of durable response to RCHOP therapy.