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Abstract #1728

Prognostic Value of Pre-Treatment DCE-MRI in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Comparison with Traditional Clinical Prognostic Parameters

Martin D. Pickles1, David J. Manton2, Martin Lowry1, Lindsay W. Turnbull1

1Centre for MR Investigations, Hull York Medical School at University of Hull, Hull, East Yorkshire, United Kingdom; 2Medical Physics, Hull & East Yorkshire Hospitals NHS Trust, Hull, East Yorkshire, United Kingdom

Reports have highlighted the prognostic value of MR parameters in predicting survival internals in breast cancer patients. However, the cohort size is generally small with short follow up intervals. The aims of this study were to determine if any associations were noted between MR parameters and survival in a large cohort with a long follow-up interval and additionally to compare their prognostic value against traditional clinical indicators. This work has revealed significant associations between MR parameters and survival intervals. Further, in this cohort MR parameters provided prognostic information superior to traditional clinical indicators as evident from the higher hazard ratios.