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Abstract #1729

An Evaluation of Global Versus Local In-Plane Rigid Registration in Dynamic Contrast-Enhanced Breast Examinations

Araminta E. W. Ledger1, Marco Borri1, Romney Pope2, Erica Scurr1, Toni Wallace1, Cheryl Richardson2, Marianne Usher2, Robin Wilson2, Steven Allen2, Karen Thomas3, Nandita M. deSouza1, Martin O. Leach1, Maria A. Schmidt1

1CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 3Clinical Research and Development, Royal Marsden Hospital, Sutton, Surrey, United Kingdom

Contrast agent (CA) uptake curve classification may be considerably affected by movement across dynamic contrast-enhanced breast examinations. This abstract retrospectively considers axillary vessel enhancement to approximate the effect of rigid in-plane registration on CA uptake curves derived from small enhancing structures. The performance of global and local registration and their impact on the shape of the CA uptake curves was investigated. Area under the curve and signal enhancement ratio differed significantly between globally and locally registered image sets versus unregistered data. CA uptake curves derived from small enhancing lesions may therefore be unreliable despite use of global rigid registration.