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Abstract #1733

MRI-Based Measurements of Breast Density and Morphologic Features for Prediction of Cancer Risk: A Case-Control Study

Jeon-Hor Chen1, 2, Ling-Chuan Chang3, Yi-Ting Wu3, Christopher Scott4, V. Shane Pankratz4, Kathleen Brandt5, Chin-Yu Chang3, Peter T. Fwu1, Xiao-Yong Wang1, Min-Ying Su1, Celine M. Vachon4

1Center for Functional Onco-Imaging,Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States; 2Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan; 3Department of Radiology, China Medical University Hospital, Taichung, Taiwan; 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States; 5Department of Radiology, Mayo Clinic, Rochester, MN, United States

The goals of this study were to examine whether breast density and morphological pattern characterized by MRI can differentiate patients with and without cancer, and further to compare their associations with cancer risk based on MRI-density, mammographic density, or combined variables. Early results from this small cohort suggest mammographic density measures are not strongly associated with breast cancer in this symptomatic population. MRI density remains a strong risk factor for breast cancer, which is consistent with results from a prior screening study.