Abstract #1769

Prostate Cancer Localization with a Multiparametric MR Approach (PCaMAP): Initial Results of a Multi-Center Study

Marnix C. Maas¹, Marit J. Koopman¹, Geert J.S. Litjens¹, Alan J. Wright¹, Kirsten M. Selns², Ingrid Susann Gribbestad², Masoom A. Haider³, Katarzyna J. Macura⁴, Daniel J.A. Margolis⁵, Berthold Kiefer⁶, Jurgen J. Ftterer¹, Tom W.J. Scheenen¹

¹Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; ²Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; ³Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada; ⁴Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; ⁵Department of Radiology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States; ⁶Siemens AG Healthcare Sector, Erlangen, Germany

This work presents initial results of a multi-center trial aimed at assessing the diagnostic accuracy of 3T multi-parametric MR imaging and spectroscopy (mpMRI) in distinguishing clinically significant prostate cancer from other prostatic tissue, with whole-mount section histopathology as the gold standard. Multi-center mpMRI with identical protocols at 3T without ERC provided homogeneous quantitative parameters for non-cancer tissues and detected significant differences between these tissues. The validation part of this prospective trial will be used to determine the parameters contributing most to the detection and localization of clinically significant PCa as well as their optimal cutoff values.