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Abstract #1770

Multiparametric MRI and Pharmakokinetic Maps for Prostate Cancer Detection: Value in a Multireader Decision Transperineal Biopsy Study

Tobias Penzkofer1, 2, Kemal Tuncali1, Andriy Fedorov1, Junichi Tokuda1, Sang-Eun Song1, Nobuhiko Hata1, Sandeep Narendra Gupta3, Robert Mulkern4, Fiona Fennessy, 15, Clare Tempany1

1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Diagnostic and Interventional Radiology, RWTH Aachen University Hospital, Aachen, NRW, Germany; 3GE Global Research, Niskyuna, NY, United States; 4Department of Radiology, Boston Children's Hospital, Boston, MA, United States; 5Department of Radiology, Dana Farber Cancer Institute, Boston, MA, United States

We present the analysis of the utility of mpMRI including quantitative imaging parameters in prostate cancer detection, and the discriminating power of the individual parameters between the biopsy sample pathology-confirmed cancer and non-cancer areas. The multireader setting yielded a high number of additional cancer diagnoses. While for all parameters scores were on average higher for histologically malignant lesions, only T2, ADC500, ADC1400, Subtraction, Ktrans, Ve and TTP showed a significant difference in score.