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Abstract #1773

Quantitative Evaluation of Treatment Related Changes on Multi-Parametric MRI After Laser Interstitial Thermal Therapy of Prostate Cancer

Satish Viswanath1, Dan Sperling2, Herbert Lepor3, Jurgen J. Futterer4, Anant Madabhushi1

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Radiology, New Jersey Institute of Radiology, Carlstadt, NJ, United States; 3Urology, NYU Langone Medical Center and School of Medicine, New York, United States; 4Radiology, Radboud University Nijmegen Medical Centre, Nijmegen , Netherlands

We present a quantitative image analysis framework which enables high-resolution evaluation of treatment-related changes in vivo for patients undergoing laser interstitial thermal therapy (LITT). Our computerized decision support framework brings different MP-MRI parameters into alignment and differentially weights their contributions for treatment evaluation. Preliminary results suggest that our framework can accurately quantify changes in MP MRI imaging markers. The integrated MP-MRI difference map showed excellent utility in quantifying the extent and types of focal treatment-related changes, in vivo.