Abstract #1773

Quantitative Evaluation of Treatment Related Changes on Multi-Parametric MRI After Laser Interstitial Thermal Therapy of Prostate Cancer

Satish Viswanath¹, Dan Sperling², Herbert Lepor³, Jurgen J. Futterer⁴, Anant Madabhushi¹

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; ²Radiology, New Jersey Institute of Radiology, Carlstadt, NJ, United States; ³Urology, NYU Langone Medical Center and School of Medicine, New York, United States; ⁴Radiology, Radboud University Nijmegen Medical Centre, Nijmegen , Netherlands

We present a quantitative image analysis framework which enables high-resolution evaluation of treatment-related changes in vivo for patients undergoing laser interstitial thermal therapy (LITT). Our computerized decision support framework brings different MP-MRI parameters into alignment and differentially weights their contributions for treatment evaluation. Preliminary results suggest that our framework can accurately quantify changes in MP MRI imaging markers. The integrated MP-MRI difference map showed excellent utility in quantifying the extent and types of focal treatment-related changes, in vivo.